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Open Access Commentary

Deciphering the role of natural variation in age-related protein homeostasis

Matt Kaeberlein

Author Affiliations

Department of Pathology, University of Washington, 1959 NE Pacific Street, D-514, Seattle, WA 98195-7470, USA

BMC Biology 2013, 11:102  doi:10.1186/1741-7007-11-102

Published: 30 September 2013


Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology.

See research article: webcite