Table 3

Genes associated with the oxidative phosphorylation pathway present in clusters 27 and 99.

Functional Grouping

Cluster 27

Cluster 99


TCA cycle

ACO2, CS, FH, IDH2, IDH3B, MDH2, SUCLG1

Oxidative phoshorylation, Complex I

NDUFA1, NDUFA10, NDUFA12, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB2, NDUFB3, NDUFB5, NDUFB6, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS6, NDUFV2, NDUFV3

MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L,

MT-ND5,

Oxidative phoshorylation, Complex II

SDHA, SDHB

Oxidative phoshorylation, Complex III

CYC1, UQCR10, UQCRB, UQCRC1, UQCRFS1, UQCRH

MT-CYB

Oxidative phoshorylation, Complex IV

COX4I1, COX5B, COX6B, COX6C, COX7B2

MT-CO1, MT-CO2, MT-CO3

Oxidative phoshorylation, Complex V

ATP5A1, ATP5C1, ATP5F1, ATP5G1, ATP5G3, ATP5J2, ATP5H

MT-ATP6

Cytochrome C biosynthesis

HCCS

Fatty acid (long chain) beta-oxidation

ACADVL, GOT2, HADHA, HADHB, PTGES2

Mitochondrial membrane transport

CHCHD3, NNT, SAMM50, TIMM8B, TOMM7, TUFM, VDAC1

Mitochondrial RNA processing

SLIRP, MRPL2, MRPS24

Ubiquinone biosynthesis

COQ6, COQ7, COQ9

Apoptosis-associated

AIFM1, DELE

Ox phos-related

BOLA3, BRP44, CHCHD10, GBAS

Unknown function

C11orf67, C6H4orf52, IMMT, LOC100060661, LOC100512781, LOC100520866, LOC100523804, SS18L2, WDR45

Gm8437, LOC100512762, LRP1B, MTRNR2L4


Coexpression of members of oxidative phosphorylation and related pathways. Nuclear (cluster 27) and mitochondrial (cluster 99) gene clusters associated with oxidative phosphorylation. The known association with pathway/protein complex is listed for each gene in the cluster. List of all genes present in clusters 27 and 99 and the function of the encoded protein, where known.

Freeman et al. BMC Biology 2012 10:90   doi:10.1186/1741-7007-10-90

Open Data