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Open Access Highly Accessed Commentary

Different noses for different mice and men

Andreas Keller

Author Affiliations

The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA

BMC Biology 2012, 10:75  doi:10.1186/1741-7007-10-75

Published: 21 August 2012

Abstract

Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics explore the genetic variation of chemosensory receptor gene repertoires in humans and mice and provide unparalleled insight into the causes and consequences of this variability.

See research articles http://www.biomedcentral.com/1471-2164/13/414 webcite and http://www.biomedcentral.com/1471-2164/13/415 webcite