Email updates

Keep up to date with the latest news and content from BMC Biology and BioMed Central.

Journal App

google play app store
Open Access Commentary

Folate status of gut microbiome affects Caenorhabditis elegans lifespan

Theresa PT Nguyen and Catherine F Clarke*

Author affiliations

UCLA Department of Chemistry and Biochemistry and the Molecular Biology Institute, 607 Charles E Young Dr E, Los Angeles, CA 90095 USA

For all author emails, please log on.

Citation and License

BMC Biology 2012, 10:66  doi:10.1186/1741-7007-10-66

Published: 31 July 2012


In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation.

See research article http://www. webcite