Schematic representation of the mechanism underlying Glu/GABA exchange. GAT-2/3 transporters are expressed on glial end feet surrounding glutamatergic synapses and colocalize with EAAT2 transporters. Glial uptake of Glu is coupled to the release of GABA by a mechanism through which Na+ that is cotransported with Glu drive the release of GABA synthesized from putrescine. The released GABA contributes to tonic inhibition of neurons.
Héja et al. BMC Biology 2012 10:26 doi:10.1186/1741-7007-10-26