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Signaling-mediated control of ubiquitin ligases in endocytosis

Simona Polo

Author Affiliations

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy

Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, Via di Rudinì 8, 20122 Milan, Italy

BMC Biology 2012, 10:25  doi:10.1186/1741-7007-10-25

Published: 15 March 2012


Ubiquitin-dependent regulation of endocytosis plays an important part in the control of signal transduction, and a critical issue in the understanding of signal transduction therefore relates to regulation of ubiquitination in the endocytic pathway. We discuss here what is known of the mechanisms by which signaling controls the activity of the ubiquitin ligases that specifically recognize the targets of ubiquitination on the endocytic pathway, and suggest alternative mechanisms that deserve experimental investigation.