Signaling-mediated control of ubiquitin ligases in endocytosis
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, Via di Rudinì 8, 20122 Milan, Italy
BMC Biology 2012, 10:25 doi:10.1186/1741-7007-10-25Published: 15 March 2012
Ubiquitin-dependent regulation of endocytosis plays an important part in the control of signal transduction, and a critical issue in the understanding of signal transduction therefore relates to regulation of ubiquitination in the endocytic pathway. We discuss here what is known of the mechanisms by which signaling controls the activity of the ubiquitin ligases that specifically recognize the targets of ubiquitination on the endocytic pathway, and suggest alternative mechanisms that deserve experimental investigation.