Ubiquitin ligases and beyond
Citation and License
BMC Biology 2012, 10:22 doi:10.1186/1741-7007-10-22Published: 15 March 2012
First paragraph (this article has no abstract)
In a review published in 2004  and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through the revelation that it has a central role in cell cycle regulation and the recognition of regulatory roles for ubiquitin in intracellular membrane transport, cell signalling, transcription, translation, and DNA repair.