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Open Access Highly Accessed Editorial

Ubiquitin ligases and beyond

Ivan Dikic1 and Miranda Robertson2

Author affiliations

1 Institute of Biochemistry II, Medical Faculty of the Goethe University, University Hospital Building 75, Theodor-Stern-Kai 7, 60528 Frankfurt am Main, Germany

2 BMC Biology, BioMed Central, 236 Gray's Inn Road, London WC1X 8HL, UK

Citation and License

BMC Biology 2012, 10:22  doi:10.1186/1741-7007-10-22

Published: 15 March 2012

First paragraph (this article has no abstract)

In a review published in 2004 [1] and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through the revelation that it has a central role in cell cycle regulation and the recognition of regulatory roles for ubiquitin in intracellular membrane transport, cell signalling, transcription, translation, and DNA repair.