Figure 2.

Because both ephrins and Eph receptors have multiple binding sites, however, Eph-ephrin binding may further form hetero-tetramer or higher oligomers if tighter cell-cell adhesion is required [11]. The figure shows the dimeric and tetrameric complexes observed in the crystal structure (PDB: 1KGY).

Nussinov and Ma BMC Biology 2012 10:2   doi:10.1186/1741-7007-10-2
Download authors' original image