Figure 1.

The extent of Hsp90 depletion affects the mechanism by which phenotypic effects are induced. To work as an evolutionary capacitor, facilitating evolvability above and beyond the effects of mutagenesis, induced variation must persist for multiple generations, but also be reversible once genetic assimilation is complete. None of the three proposed effects of Hsp90 depletion clearly meets both hurdles.

Siegal and Masel BMC Biology 2012 10:14   doi:10.1186/1741-7007-10-14
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