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Open Access Highly Accessed Research

Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats

Gayle A Orner1*, Bill D Roebuck2, Roderick H Dashwood13 and George S Bailey13

Author Affiliations

1 Linus Pauling Institute, Oregon State University, Corvallis, OR, USA

2 Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH, USA

3 Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR, USA

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Journal of Carcinogenesis 2006, 5:6  doi:10.1186/1477-3163-5-6

Published: 6 February 2006

Abstract

Chlorophyllin (CHL) is a promising chemopreventive agent believed to block cancer primarily by inhibiting carcinogen uptake through the formation of molecular complexes with the carcinogens. However, recent studies suggest that CHL may have additional biological effects particularly when given after the period of carcinogen treatment. This study examines the post-initiation effects of CHL towards aflatoxin B1 (AFB1)-induced preneoplastic foci of the liver and colon. The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats.