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Open Access Highly Accessed Research article

Media reporting of tenofovir trials in Cambodia and Cameroon

Edward Mills12*, Beth Rachlis1, Ping Wu3, Elaine Wong4, Kumanan Wilson5 and Sonal Singh6

Author Affiliations

1 Dept. of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada

2 Centre for International Human Rights Law, University of Oxford, Oxford, UK

3 Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

4 Development Studies Institute, London School of Economics, London, UK

5 Departments of Medicine, Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada

6 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA

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BMC International Health and Human Rights 2005, 5:6  doi:10.1186/1472-698X-5-6

Published: 24 August 2005

Abstract

Background

Two planned trials of pre-exposure prophylaxis tenofovir in Cambodia and Cameroon to prevent HIV infection in high-risk populations were closed due to activist pressure on host country governments. The international news media contributed substantially as the primary source of knowledge transfer regarding the trials. We aimed to characterize the nature of reporting, specifically focusing on the issues identified by media reports regarding each trial.

Methods

With the aid of an information specialist, we searched 3 electronic media databases, 5 electronic medical databases and extensively searched the Internet. In addition we contacted stakeholder groups. We included media reports addressing the trial closures, the reasons for the trial closures, and who was interviewed. We extracted data using content analysis independently, in duplicate.

Results

We included 24 reports on the Cambodian trial closure and 13 reports on the Cameroon trial closure. One academic news account incorrectly reported that it was an HIV vaccine trial that closed early. The primary reasons cited for the Cambodian trial closure were: a lack of medical insurance for trial related injuries (71%); human rights considerations (71%); study protocol concerns (46%); general suspicions regarding trial location (37%) and inadequate prevention counseling (29%). The primary reasons cited for the Cameroon trial closure were: inadequate access to care for seroconverters (69%); participants not sufficiently informed of risks (69%); inadequate number of staff (46%); participants being exploited (46%) and an unethical study design (38%). Only 3/23 (13%) reports acknowledged interviewing research personnel regarding the Cambodian trial, while 4/13 (30.8%) reports interviewed researchers involved in the Cameroon trial.

Conclusion

Our review indicates that the issues addressed and validity of the media reports of these trials is highly variable. Given the potential impact of the media in formulation of health policy related to HIV, efforts are needed to effectively engage the media during periods of controversy in the HIV/AIDS epidemic.