Table 2

Performance of various definitions for heart failure in derivation set (n = 300)*

#

Heart failure criteria based on claims and laboratory data

Sensitivity

Specificity

AUC


1

≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR BNP ≥ 200 pg/ml

76.29

74.53

0.754


2

≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure

68.56

81.13

0.748


3

≥2 heart failure encounters OR BNP ≥ 200 pg/ml

69.59

79.25

0.744


4

≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml

69.59

78.3

0.739


5

≥2 heart failure encounters OR primary hospital discharge diagnosis of heart failure

60.31

85.85

0.729


6

≥2 heart failure encounters OR BNP ≥ 100 pg/ml

76.29

68.87

0.726


7

≥2 heart failure encounters

58.76

85.85

0.723


8

≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR any hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 200 pg/ml

59.28

81.13

0.702


9

≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR primary hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 500 pg/ml

38.66

90.57

0.646


10

Any hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml

40.72

87.74

0.642


11

Any hospital discharge diagnosis of heart failure

35.05

91.51

0.633


12

BNP ≥ 100 pg/ml

48.97

76.42

0.627


13

BNP ≥ 200 pg/ml

36.08

87.74

0.619


14

Primary hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml

24.23

95.28

0.598


15

BNP ≥ 500 pg/ml

20.1

95.28

0.577


16

Any primary hospital discharge diagnosis of heart failure

14.95

100

0.575


*Calculated sensitivity, specificity, and area under curve for each claim signature is compared to the Framingham definition of heart failure (i.e., meeting either two major criteria or one major and two minor criteria).

Alqaisi et al. BMC Health Services Research 2009 9:237   doi:10.1186/1472-6963-9-237

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