|
Example of an evidence profile summary of findings given to the evaluators for them to grade in the pilot study. Example question: Should depressed patients in primary care be treated with SSRIs rather than tricyclics? |
||||||
| Outcome |
SSRI |
tricyclics |
Effect |
Quality |
Relative importance |
|
|
|
||||||
| Relative (95% CI) |
NNT/NNH |
|||||
|
|
||||||
| Depression Severity |
5044 patients |
4510 patients |
WMD 0.034 (-0.007 to 0.075) |
No difference |
||
| Transient side effects |
1948/7032 (28%) |
2072/6334 (33%) |
RRR 13% (5% to 20%) |
20 |
||
| Poisoning fatalities* |
1/100,000 per year of treatment |
58/100,000 per year of treatment |
RRR 98% |
1754 |
||
|
* Uncertainty about baseline risk: Fatality data may be influenced by which pills are given to whom, and it is uncertain if changing antidepressant would deter suicide attempts | ||||||
Atkins et al. BMC Health Services Research 2005 5:25 doi:10.1186/1472-6963-5-25 |
||||||