Table 4

Test and performance characteristics of claims–based definitions for febrile neutropenia
Gold standard:
FN: No FN: FN: No FN: FN: No FN: FN: No FN: FN: No FN:
Claims–Based Definitions: FN: 47 7 FN: 55 16 FN: 28 0 FN: 55 23 FN: 71 130
No FN: 35 268 No FN: 27 259 No FN: 54 275 No FN: 27 252 No FN: 11 145
Test/Performance Characteristic* Neutropenia, Primary Position Neutropenia, Any Position Neutropenia + Fever,Any Position Neutropenia or Fever, Any Position Neutropenia, Fever, or Infection, Any Position
 Patient Classification, %
  True–Positive 13% (10–17) 15% (11–19) 8% (5–11) 15% (11–19) 20% (16–24)
  False–Positive 2% (0–3) 4% (2–7) 0% (–––) 6% (4–9) 36% (31–42)
  True–Negative 75% (70–79) 73% (68–77) 77% (73–81) 71% (66–75) 41% (36–45)
  False–Negative 10% (7–13) 8% (5–10) 15% (11–18) 8% (5–10) 3% (1–5)
 Sensitivity, % 57% (46–68) 67% (56–77) 34% (24–45) 67% (56–77) 87% (79–94)
 Specificity, % 97% (96–99) 94% (91–97) 100% (–––) 92% (88–95) 53% (47–59)
 Positive Predictive Value (PPV), % 87% (78–95) 77% (68–87) 100% (–––) 71% (61–80) 35% (29–42)
 Negative Predictive Value (NPV), % 88% (85–92) 91% (87–94) 84% (80–87) 90% (87–94) 93% (89–97)
 Accuracy, % 88% (85–91) 88% (85–91) 85% (82–89) 86% (82–90) 61% (55–66)
 Likelihood ratio positive (LR+) 22.5 (12.3–68.5) 11.5 (7.6–20.4) ––– 8.0 (5.6–13.4) 1.8 (1.6–2.1)
 Likelihood ratio negative (LR–) 0.4 (0.3–0.6) 0.3 (0.2–0.5) 0.7 (0.6–0.8) 0.4 (0.3–0.5) 0.3 (0.1–0.4)

FN: febrile neutropenia.

*Value (95% CI).

Weycker et al.

Weycker et al. BMC Health Services Research 2013 13:60   doi:10.1186/1472-6963-13-60

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