Open Access Open Badges Research article

The cost of first-ever stroke in Valle d’Aosta, Italy: linking clinical registries and administrative data

Edo Bottacchi1*, Giovanni Corso1, Piera Tosi1, Massimo Veronese Morosini2, Giuseppe De Filippis3, Laura Santoni4, Gianluca Furneri5 and Cristina Negrini6

Author Affiliations

1 Department of Neurology, Regional Hospital of Aosta Valley, Aosta, Italy

2 Department of Statistics, Regional Hospital of Aosta Valley, Aosta, Italy

3 Healthcare Direction, AUSL of Aosta Valley, Aosta, Italy

4 Department of Outcome Research Pfizer, Rome, Italy

5 Scientific Direction, Italian National Research Center on Aging (I.N.R.C.A.), Ancona, Italy

6 Life Science Division, Simon-Kucher & Partners, Milan, Italy

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BMC Health Services Research 2012, 12:372  doi:10.1186/1472-6963-12-372

Published: 30 October 2012



Stroke is one of the most relevant reasons of death and disability worldwide. Many cost of illness studies have been performed to evaluate direct and indirect costs of ischaemic stroke, especially within the first year after the acute episode, using different methodologies.


We conducted a longitudinal, retrospective, bottom-up cost of illness study, to evaluate clinical and economic outcomes of a cohort of patients affected by a first cerebrovascular event, including subjects with ischaemic, haemorrhagic or transient episodes. The analysis intended to detect direct costs, within 1, 2 and 3 years from the index event. Clinical patient data collected in regional disease registry were integrated and linked to regional administrative databases to perform the analysis.


The analysis of costs within the first year from the index event included 800 patients. The majority of patients (71.5%) were affected by ischaemic stroke. Overall, per patient costs were €7,079. Overall costs significantly differ according to the type of stroke, with costs for haemorrhagic stroke and ischaemic stroke amounting to €9,044 and €7,289. Hospital costs, including inpatient rehabilitation, were driver of expenditure, accounting for 89.5% of total costs. The multiple regression model showed that sex, level of physical disability and level of neurological deficit predict direct healthcare costs within 1 year. The analysis at 2 and 3 years (per patient costs: €7,901 and €8,874, respectively) showed that majority of costs are concentrated in the first months after the acute event.


This cost analysis highlights the importance to set up significant prevention programs to reduce the economic burden of stroke, which is mostly attributable to hospital and inpatient rehabilitation costs immediately after the acute episode. Although some limitation typical of retrospective analyses the approach of linking clinical and administrative database is a power tool to obtain useful information for healthcare planning.

Stroke; Costs; Italy; Prevention; Administrative claims; Record linkage