Table 4

Sensitivity, specificity, PPV, and NPV for various predicted probabilities of COPD from logistic model 8 by diagnostic standard

GOLD diagnostic standard (model 8)


Model-based predicted probability of COPD (95% CI)


Performance characteristic (%)

≥0.25

≥0.50

≥0.75


Sensitivity

90.9 (90.0-91.7)

71.9 (70.6-73.2)

35.7 (34.3-37.1)

Specificity

40.5 (39.2-41.9)

73.5 (72.3-74.8

92.2 (91.4-92.9)

PPV

58.2 (57.0-59.3)

71.2 (69.9-72.5)

80.7 (78.9-82.4)

NPV

83.0 (81.3-84.5)

74.2 (72.9-75.4)

61.1 (60.0-62.2)


LLN diagnostic standard (model 8)


Model-based predicted probability of COPD (95% CI)


Performance characteristic (%)

≥0.25

≥0.50

≥0.75


Sensitivity

83.1 (81.9-84.4)

59.8 (58.2-61.4)

7.5 (6.6-8.4)

Specificity

55.9 (54.6-57.2)

79.6 (78.6-80.6)

98.8 (98.5-99.1)

PPV

54.1 (52.7-55.4)

64.6 (63.0-66.3)

80.1 (75.5-84.2)

NPV

84.2 (83.0-85.3)

76.0 (75.0-77.1)

63.1 (62.1-64.1)


LLN, lower limit of normal; PPV, positive predictive value; NPV, negative predictive value

Cooke et al. BMC Health Services Research 2011 11:37   doi:10.1186/1472-6963-11-37

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