Table 2 |
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|
Current population pharmacokinetic parameter priors used to forecast methotrexate plasma concentrations in pediatric patients |
|||
|
Parameter |
Units |
Estimate |
BSV |
|
|
|||
|
CLN |
L/h |
8.13 |
41.2% |
|
CLR |
L/h |
2.59 |
82.0% |
|
V1 |
L |
39.6 |
21.0% |
|
V2 |
L |
3.94 |
47.6% |
|
Q |
L/h |
0.113 |
7.56% |
|
|
|||
|
CLN – Clearance in patients with normal renal function CLR – Clearance in patients with reduced renal function V1 – Volume of distribution in the central compartment V2 – Volume of distribution in the peripheral compartment Q – Inter-compartmental clearance BSV – Between subject variability |
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|
Barrett et al. BMC Medical Informatics and Decision Making 2008 8:6 doi:10.1186/1472-6947-8-6 |
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