Table 2

Urinary excretion of toxic metals in Phase 1, at baseline, after 1st dose, and after 9th dose, in mcg/g creatinine.

Element

Baseline

1st Dose

9th Dose

1st dose vs. baseline

9th dose vs. baseline


Pb

1.3 +/- 2.3

10. +/- 19.

9.2 +/- 7.8

713%***

638%***

Sn

2.3 +/- 3.4

8.0 +/- 13

9.7 +/- 24

241%***

314%*

Bi

0.18 +/- 0.45

0.47 +/- 1.4

0.41 +/- 1.0

161%+

128%*

U

0.015 +/- .04

0.036 +/- .09

0.031 +/- .1

104%

111%

Hg

0.86 +/- .92

1.5 +/- 1.4

0.97 +/- 0.88

70%**

13%

Tl

0.15 +/- 0.12

0.25 +/- 0.18

0.21 +/- 0.19

67%***

42%**

Sb

0.10 +/- 0.10

0.15 +/- 0.19

0.14 +/- 0.20

49%*

42%+

W

0.39 +/- 0.29

0.59 +/- 0.63

0.46 +/- 0.50

51%**

18%*

Al

16 +/- 21

18 +/- 23

19 +/- 33

11%

21%

Ni

6.7 +/- 5.1

5.5 +/- 3.6

7.6 +/- 4.3

-18%*

12%

Cd

0.38 +/- 0.24

0.40 +/- 0.24

0.33 +/- 0.23

5%

-14%

As

32 +/- 20

32 +/- 18

25 +/- 18

0%

-19%*

creatinine

94 +/- 52

62 +/- 39

80 +/- 43

-34%***

-15%*


+ P < 0.1

*P < 0.05

** P < 0.01

*** P < 0.001

Creatinine values have units of mg/dl. N = 63. The metals are listed in approximate order of effect of DMSA on excretion. Significant results are highlighted in bold font.

Adams et al. BMC Clinical Pharmacology 2009 9:16   doi:10.1186/1472-6904-9-16

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