Table 12

Stepwise linear regression analysis of change in platelet count (from baseline to beginning of phase 2, 1-2 months after DMSA therapy), based on excretion of metals after the 9th dose in phase one, and the change in glutathione.

Adjusted R2

P- value

Equation

Most Significant Variables


Change in platelet count (both groups, n = 32)

0.41

0.02

7rnd group (3.71-331Tl9 +256Sb9+2.89As9-256Cd9-0.118Dglut) 1rnd group (-81.6 +28.3Tl9- 174Sb9+0.194As9+259Cd9+0.193Dglut)

7rnd - (Tl9***, As9**, Cd9*, Dglut*), 1rnd- (Dglut*)

Change in platelet count (7-rnd group only, n = 20)

0.41

0.02

3.71 -331 Tl9 +256Sb9 +2.89 As9 -256 Cd9 -0.118 DGlut

Tl9**, As9**, Cd*, DGlut*


Thallium (Tl), Arsenic (As), Cadmium (Cd), and change in glutathione (Dglut) are the best predictors of change in platelet count, for the case of analyzing both groups and for the case of the 7-round group only.

Adams et al. BMC Clinical Pharmacology 2009 9:16   doi:10.1186/1472-6904-9-16

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