Table 12 

Stepwise linear regression analysis of change in platelet count (from baseline to beginning of phase 2, 12 months after DMSA therapy), based on excretion of metals after the 9^{th }dose in phase one, and the change in glutathione. 

Adjusted R^{2} 
P value 
Equation 
Most Significant Variables 



Change in platelet count (both groups, n = 32) 
0.41 
0.02 
7rnd group (3.71331Tl9 +256Sb9+2.89As9256Cd90.118Dglut) 1rnd group (81.6 +28.3Tl9 174Sb9+0.194As9+259Cd9+0.193Dglut) 
7rnd  (Tl9***, As9**, Cd9*, Dglut*), 1rnd (Dglut*) 
Change in platelet count (7rnd group only, n = 20) 
0.41 
0.02 
3.71 331 Tl9 +256Sb9 +2.89 As9 256 Cd9 0.118 DGlut 
Tl9**, As9**, Cd*, DGlut* 


Thallium (Tl), Arsenic (As), Cadmium (Cd), and change in glutathione (Dglut) are the best predictors of change in platelet count, for the case of analyzing both groups and for the case of the 7round group only. 

Adams et al. BMC Clinical Pharmacology 2009 9:16 doi:10.1186/14726904916 