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Peak Changes in VAS Subjective Variables in Response to Inhaled l-Methamphetamine, IV phenylephrine and IV l-methamphetamine. |
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| Measure |
16 Inhalations |
32 Inhalations |
64 Inhalations |
PE1 |
PE2 |
IV l-Meth |
Overall P-Value |
|
|
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| Any Drug Effect |
9.0 (13.9)§||** |
7.3 (10.5)§||** |
9.8 (7.9)§||¶** |
1.5 (2.1) |
1.7 (2.4) |
4.5 (8.6) |
0.001 |
| Bad Drug Effect |
6.8 (13.7) |
2.8 (4.6) |
4.9 (5.0) |
0.33 (0.9) |
1.1 (0.79) |
5.3 (10.7) |
0.07 |
| Dizziness |
9.3 (14.0)§||¶** |
6.5 (6.4)¶** |
9.0 (13.5)§||¶** |
1.5 (2.9) |
0.92 (2.2) |
-0.67 (5.7) |
0.004 |
| Good Drug Effect |
5.8 (13.0)||** |
5.7 (10.5)** |
9.7 (13.0)§||¶** |
0.42 (2.9) |
0.25 (1.5) |
2.7 (4.7) |
0.005 |
| Headache |
5.1 (18.1) |
4.8 (5.1)|| |
12.7 (17.0)§||¶** |
-0.08 (1.7) |
1.8 (3.3) |
-3.8 (13.4) |
0.02 |
| Nasal Dryness |
5.2 (16.2) |
3.3 (9.6) |
4.1 (9.9) |
-0.75 (2.1) |
-0.50 (1.7) |
-0.42 (2.7) |
0.20 |
| Nasal Stuffiness |
1.1 (16.9) |
2.8 (4.8) |
1.4 (6.7) |
0.50 (4.4) |
-1.6 (3.6) |
0.42 (1.2) |
0.88 |
|
Data presented as mean (SD). PE1 = phenylephrine dose 1; PE2 = phenylephrine dose 2; IV l -Meth = IV l-methamphetamine *= significantly greater than 16 inhalations † = significantly greater than 32 inhalations ‡ = significantly greater than 64 inhalations § = significantly greater than PE1 || = significantly greater than PE2 ¶ significantly greater than IV l-methamphetamine ** = significantly greater than baseline | |||||||
Mendelson et al. BMC Clinical Pharmacology 2008 8:4 doi:10.1186/1472-6904-8-4 |
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