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Results of single dose trials in dental and postsurgical pain for comparison of dexketoprofen with placebo, and dexketoprofen with ketoprofen |
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| Dexketoprofen versus placebo |
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|
|
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| Number of |
Percent of patients with at least 50% pain relief |
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|
|
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| Dexketoprofen dose (mg) |
Trials |
Patients |
Dexketoprofen |
Placebo |
Relative benefit (95% CI) |
NNT (95% CI) |
|
|
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| All trials |
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| 10/12.5 mg |
5 |
462 |
45 |
17 |
3.4 (2.2 to 5.6) |
3.5 (2.7 to 4.9) |
| 20/25 mg |
5 |
455 |
50 |
17 |
3.9 (2.4 to 6.3) |
3.0 (2.4 to 3.9) |
| 50 mg |
1 |
67 |
56 |
8 |
6.7 (1.7 to 26) |
2.1 (1.5 to 3.5) |
|
|
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| Dental |
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| 10/12.5 mg |
3 |
261 |
47 |
13 |
3.5 (2.2 to 5.6) |
3.0 (2.3 to 4.4) |
| 20/25 mg |
3 |
254 |
52 |
13 |
3.9 (2.4 to 6.3) |
2.6 (2.0 to 3.5) |
| 50 mg |
1 |
67 |
56 |
8 |
6.7 (1.7 to 26) |
2.1 (1.5 to 3.5) |
|
|
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| Postsurgical |
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| 10/12.5 mg |
2 |
201 |
43 |
21 |
2.1 (1.4 to 3.3) |
4.4 (2.8 to 9.7) |
| 20/25 mg |
2 |
201 |
47 |
21 |
2.3 (1.5 to 3.6) |
3.7 (2.5 to 7.0) |
|
|
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| Dexketoprofen versus ketoprofen |
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|
|
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| Number of |
Percent of patients with at least 50% pain relief |
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|
|
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| Dexketoprofen/ketoprofen dose (mg) |
Trials |
Patients |
Dexketoprofen |
Ketoprofen |
Relative benefit (95% CI) |
NNT (95% CI) |
|
|
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| All trials |
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| 12.5 vs 50 |
3 |
287 |
44 |
35 |
0.8 (0.5 to 1.2) |
not calculated |
| 25 vs 50 |
3 |
284 |
51 |
35 |
1.1 (0.7 to 1.5) |
not calculated |
| 50 vs 100 |
1 |
247 |
82 |
77 |
1.1 (0.9 to 1.2) |
not calculated |
|
|
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| 25/50 vs 50/100 |
4 |
531 |
65 |
54 |
1.2 (1.1 to 1.4) |
8.8 (5.1 to 33) |
Moore and Barden BMC Clinical Pharmacology 2008 8:11 doi:10.1186/1472-6904-8-11 |
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