Research article

Influence of an e-mail with a drug information attachment on sales of prescribed drugs: a randomized controlled study

Christina Edward¹ , Anders Himmelmann² and Susanna M Wallerstedt²

¹Department of Health, Pharmaceutical Unit, Regionens hus, SE-405 44 Göteborg, Sweden

²Department of Clinical Pharmacology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden

author email corresponding author email

BMC Clinical Pharmacology 2007, 7:12doi:10.1186/1472-6904-7-12

Published:	18 October 2007

Abstract

Background

To provide doctors with producer-independent information to facilitate choice of treatment is an important task. The objective of the present study was to evaluate if an e-mail with a drug information attachment has effects on sales of prescribed drugs and if the design of the attachment is of importance.

Methods

The Swedish pharmaceutical benefit board found rizatriptan (Maxalt^®) 10 mg to be the most cost-effective triptan. All 119 heads of primary care units in western Sweden were randomized to receive information concerning this conclusion via (i) e-mail with attachment I, (ii) e-mail with attachment II or (iii) no information (control). Attachment I was a short one (heading plus three lines text), whereas attachment II was a long one (heading plus one page text and one page with tables). The change in percentage rizatriptan of total triptans sold before and after the intervention (May – July 2004 and May – July 2005, respectively) was compared between the groups.

Results

Totally 48,229 (2004) and 50,674 (2005) defined daily doses of triptans were prescribed and sold during May – July in primary care units in the western part of Sweden. The absolute change in percentage rizatriptan was greater in the intervention groups compared with the control group 2 (25^th – 75^th percentile: -3 – 7) vs 0 (-7 - 5), P = 0.031). The absolute change in percentage rizatriptan did not differ between the two attachment groups (P = 0.93).

Conclusion

An e-mail with a drug information attachment may influence sales of prescribed drugs. No difference between different designs of the attachment could be detected.