Figure 2.

Dose proportionality of nicotine lozenges with respect to nicotine plasma concentrations (31 subjects). Nicotine plasma concentrations were determined from blood samples of 31 volunteers drawn before hourly administration 1 or 2 mg nicotine lozenge (unconnected data points). Consecutive blood samples (connected data points) were drawn after administration of dose 12 (t = 11 h), and the derived data points are connected. Plasma concentrations obtained with 1 mg lozenges were doubled for ease of comparison.