Table 2

Calculated pharmacokinetic parameters of components or metabolites after intake of a single dose of 300 mg Pycnogenol.

Compound

n

AUC _[0-t] [ng/mL × h]

AUC _[t-8] [ng/mL × h]

c_max [ng/mL]

t_max [h]

term t½ [h]

Caffeic acid

9

75.66 ± 33.53

82.78 ± 36.47

16.67 ± 13.29

3.7 ± 2.4

4.42 ± 2.47

Catechin

9

107.22 ± 55.49

3.2 ± 1.7

Taxifolin

6

231.11 ± 85.98

399.14 ± 98.95

33.34 ± 12.54

8.2 ± 2.5

8.89 ± 2.81

Ferulic acid

7

99.05 ± 28.09

141.19 ± 73.90

14.78 ± 5.89

1.2 ± 1.1

6.87 ± 3.83

M1

8

4.11 ± 2.08

10.0 ± 1.9

Abbreviations: n – number of volunteers with detectable compound concentrations; AUC – area under the curve, "t" symbolizes the time of last plasma sampling (14 h); c_max – maximal plasma concentration, t_max – time of maximal plasma concentration; term t½ – terminal half-life of compound. Values represent means and standard deviations. These calculations were based on the determined free concentration of the respective compound in the extract and based on the assumption that no additional caffeic or ferulic acid was metabolically generated.

Grimm et al. BMC Clinical Pharmacology 2006 6:4   doi:10.1186/1472-6904-6-4