Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat

doi:10.1186/1472-6904-6-1

BMC Clinical Pharmacology

Volume 6

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Research article

Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat

David G Levitt¹ and Rik C Schoemaker²

¹Department of Physiology, University of Minnesota, 6-125 Jackson Hall, 321 Church St. S. E., Minneapolis, MN 55455, USA

²Centre for Human Drug Research Zernikedreef 10, 2333CL Leiden, The Netherlands

author email corresponding author email

BMC Clinical Pharmacology 2006, 6:1doi:10.1186/1472-6904-6-1


Published:	6 January 2006

Additional files

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Section I: Detailed derivation of mathematical description of slow tight binding solutes. Section II: Derivation of relationship between 60 minute ACE assay and true in vivo ACE activity. Section III: Analysis of the sensitivity of the model predictions to parameter variations for IV ramiprilat. Section IV: Analysis of the sensitivity of the model predictions to parameter variations for IV and oral ramipril.

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