Table 3

Individual and mean pharmacokinetic parameters of genistein following a single dose of orally administered soy beverage (B) and soy extract capsules (C).

Subj No.

Cmax (ng/ml)

Cmax/Dose1

AUC0–32 (ng.h/ml)

AUC0–32/Dose1

AUC0-∝ (ng.h/ml)

AUC0-∝/Dose1

Tmax (h)

t1/2 (h)


B

C

B

C

B

C

B

C

B

C

B

C

B

C

B

C


1

90.41

151.49

8.60

6.71

954.82

1950.40

90.85

86.42

1040.69

2248.09

99.02

99.61

6

6

8.46

9.92

2

68.08

124.90

6.48

5.53

693.31

1821.17

65.97

80.69

739.89

1941.50

70.40

86.02

1

8

7.62

7.42

3

149.53

301.34

14.23

13.35

1801.34

4392.34

171.39

194.61

1989.66

5048.92

189.31

223.70

8

8

8.25

9.37

4

212.94

516.77

20.26

22.90

1979.53

5541.88

188.35

245.54

2140.25

6175.55

203.64

273.62

6

6

8.10

8.93

5

96.95

220.38

9.22

9.76

1281.58

2478.42

121.94

109.81

1423.11

3072.33

135.41

136.12

8

10

9.73

12.40

6

96.57

301.62

9.19

13.36

1277.75

2776.28

121.57

123.01

1483.87

2972.50

141.19

131.70

10

6

10.10

7.74

7

223.77

371.31

21.29

16.45

3184.25

5260.83

302.97

233.09

4022.02

6003.94

382.69

266.01

4

8

12.60

9.58

8

110.60

193.01

10.52

8.55

948.75

2217.44

90.27

98.25

998.31

2370.24

94.99

105.02

6

6

5.07

8.41

9

54.86

183.88

5.22

8.15

425.80

1481.47

40.51

65.64

527.69

1500.60

50.21

66.49

4

6

4.41

4.80

10

69.95

214.54

6.66

9.51

773.90

1856.73

73.63

82.27

789.07

1940.05

75.08

85.96

6

6

5.34

6.63

11

105.13

217.57

10.00

9.64

1128.81

3121.71

107.40

138.31

1177.74

3208.73

112.06

142.17

6

8

6.32

5.27

12

117.61

345.31

11.19

15.30

871.60

2591.36

82.93

114.81

914.46

2631.99

87.01

116.61

4

6

5.35

5.05


Mean

116.37

261.84ND

11.07

11.60

1276.79

2957.50ND

121.48

131.04

1437.23

3259.54ND

136.75

144.42

5.75

7.00

7.61

7.96


SD

53.80

110.68

5.12

4.90

746.04

1372.13

70.98

60.79

949.02

1599.34

90.30

70.86

2.34

1.35

2.44

2.28


1Pharmacokinetic parameters adjusted for oral administered dose. ND = statistical analysis was not performed due to differences in oral administered doses between both preparations.

Anupongsanugool et al. BMC Clinical Pharmacology 2005 5:2   doi:10.1186/1472-6904-5-2

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