Table 3

Individual and mean pharmacokinetic parameters of genistein following a single dose of orally administered soy beverage (B) and soy extract capsules (C).
Subj No.
 Cmax (ng/ml)
 Cmax/Dose1
 AUC0–32 (ng.h/ml)
 AUC0–32/Dose1
 AUC0-∝ (ng.h/ml)
 AUC0-∝/Dose1
 Tmax (h)
 t1/2 (h)


B
 C
 B
 C
 B
 C
 B
 C
 B
 C
 B
 C
 B
 C
 B
 C
1
 90.41
 151.49
 8.60
 6.71
 954.82
 1950.40
 90.85
 86.42
 1040.69
 2248.09
 99.02
 99.61
 6
 6
 8.46
 9.92
2
 68.08
 124.90
 6.48
 5.53
 693.31
 1821.17
 65.97
 80.69
 739.89
 1941.50
 70.40
 86.02
 1
 8
 7.62
 7.42
3
 149.53
 301.34
 14.23
 13.35
 1801.34
 4392.34
 171.39
 194.61
 1989.66
 5048.92
 189.31
 223.70
 8
 8
 8.25
 9.37
4
 212.94
 516.77
 20.26
 22.90
 1979.53
 5541.88
 188.35
 245.54
 2140.25
 6175.55
 203.64
 273.62
 6
 6
 8.10
 8.93
5
 96.95
 220.38
 9.22
 9.76
 1281.58
 2478.42
 121.94
 109.81
 1423.11
 3072.33
 135.41
 136.12
 8
 10
 9.73
 12.40
6
 96.57
 301.62
 9.19
 13.36
 1277.75
 2776.28
 121.57
 123.01
 1483.87
 2972.50
 141.19
 131.70
 10
 6
 10.10
 7.74
7
 223.77
 371.31
 21.29
 16.45
 3184.25
 5260.83
 302.97
 233.09
 4022.02
 6003.94
 382.69
 266.01
 4
 8
 12.60
 9.58
8
 110.60
 193.01
 10.52
 8.55
 948.75
 2217.44
 90.27
 98.25
 998.31
 2370.24
 94.99
 105.02
 6
 6
 5.07
 8.41
9
 54.86
 183.88
 5.22
 8.15
 425.80
 1481.47
 40.51
 65.64
 527.69
 1500.60
 50.21
 66.49
 4
 6
 4.41
 4.80
10
 69.95
 214.54
 6.66
 9.51
 773.90
 1856.73
 73.63
 82.27
 789.07
 1940.05
 75.08
 85.96
 6
 6
 5.34
 6.63
11
 105.13
 217.57
 10.00
 9.64
 1128.81
 3121.71
 107.40
 138.31
 1177.74
 3208.73
 112.06
 142.17
 6
 8
 6.32
 5.27
12
 117.61
 345.31
 11.19
 15.30
 871.60
 2591.36
 82.93
 114.81
 914.46
 2631.99
 87.01
 116.61
 4
 6
 5.35
 5.05
Mean
 116.37
 261.84ND
 11.07
 11.60
 1276.79
 2957.50ND
 121.48
 131.04
 1437.23
 3259.54ND
 136.75
 144.42
 5.75
 7.00
 7.61
 7.96
SD
 53.80
 110.68
 5.12
 4.90
 746.04
 1372.13
 70.98
 60.79
 949.02
 1599.34
 90.30
 70.86
 2.34
 1.35
 2.44
 2.28

1Pharmacokinetic parameters adjusted for oral administered dose. ND = statistical analysis was not performed due to differences in oral administered doses between both preparations.

Anupongsanugool et al. BMC Clinical Pharmacology 2005 5:2   doi:10.1186/1472-6904-5-2