Research article
S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo
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* Corresponding author: José Pedraza-Chaverrí pedraza@servidor.unam.mx
1 Facultad de Química, Edificio B, Segundo Piso, Laboratorio 209, Departamento de Biología, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, 04510, México, D.F., México
2 Facultad de Química, Edificio B, Laboratorio 124, Departmento de Química Orgánica, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria 04510, México, D.F., México
3 Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Departmento de Patología, 14000, México, D.F., México
BMC Clinical Pharmacology 2004, 4:5 doi:10.1186/1472-6904-4-5
Published: 30 April 2004Additional files
Additional File 1:
Inability of SAMC to scavenge superoxide anions (O2•-) (A) and hydrogen peroxide (H2O2) (B). Data are mean ± SEM.n = 3–4. Scavenging activity of SAMC for superoxide anions (O2•-) and hydrogen peroxide (H2O2) was tested in vitro according to the methods described in Material and Methods. In both cases we were unable to see scavenging activity of SAMC. The highest concentration of SAMC that we could use in these particular assays was 0.5 mM.
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