Figure 12.

Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for dicloxacillin from Lofgren et. al. [63]. The top row is the optimal fit for the case of a capillary permeability limitation (fclear [muscle] = 0.25, PS_muscle = 11 ml/min/100 gm, average error = 12%. The bottom row is the best fit for the flow limited case (fclear = 1, average error = 18%).