Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for dicloxacillin from Lofgren et. al. . The top row is the optimal fit for the case of a capillary permeability limitation (fclear [muscle] = 0.25, PSmuscle = 11 ml/min/100 gm, average error = 12%. The bottom row is the best fit for the flow limited case (fclear = 1, average error = 18%).
Levitt BMC Clinical Pharmacology 2003 3:3 doi:10.1186/1472-6904-3-3