Table 3

Distribution of the observed concentrations of panitumumab relative to the 90% predictive interval

Distribution in Relation to 90% Prediction Interval

Antibody-Positive Patients

Antibody-Negative Patients

P-value



N

%

95% CI

P-value*

N

%

95% CI

P-value*


Below

2

5.3

0.6 -17.8

0.07

3

4.4

0.9 - 12.4

0.13

0.88

Above

5

13.2

4.4 - 28.1

7

10.3

4.2 - 20.1

Within

31

81.6

65.7 - 92.3

58

85.3

74.6 - 92.7


*Chi-square test with hypothesized proportions (5% below, 5% above, 90% within).

Chi-square test of antibody-positive proportion vs antibody-negative proportion.

Weeraratne et al. BMC Clinical Pharmacology 2011 11:17   doi:10.1186/1472-6904-11-17

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