Table 8

Effect of concomitant use of aspirin and NSAIDs among current users as compared to non use of either drug (multiple users of NSAIDs were excluded).

All cases (UGIB/Perforation)

Controls

Adjusted RR^*

(N=2,105)

(N=11,500)

(95%CI)

Low-medium-dose NSAIDs only

83(71/12)

256

2.6 (2.0-3.4)

High-dose^# NSAIDs only

254 (202/52)

413

4.3 (3.6-5.2)

Only aspirin

221 (201/20)

767

2.1 (1.8-2.5)

Aspirin + low-medium-dose NSAIDs

9 (6/3)

34

2.2 (1.0-4.6)

Aspirin + high-dose^# NSAIDs

57 (41/16)

36

13.3 (8.5-20.9)

^*Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of anticoagulants, steroids, SSRIs and paracetamol. # High-dose NSAIDs: Aceclofenac > 100, acemetacin > 120, diclofenac > 75, etodolac > 400, fenbufen > 900, fenoprofen > 1200, flurbiprofen > 150, ibuprofen > 1200, indometacin > 75, ketoprofen > 100, mefenamic acid > 1000, tiaprofenic acid > 450, azapropazone > 600, meloxicam > 7.5, nabumetone > 1000, naproxen > 500, piroxicam > 10, sulindac > 200, tenoxicam > 10 (all doses in mg).

de Abajo and García Rodríguez BMC Clinical Pharmacology 2001 1:1   doi:10.1186/1472-6904-1-1