Table 4

Analysis of disagreements between molecular (sputum specimens and cultures) and phenotypical DST results

Molecular DST

Phenotypical DST


Sputum

Culture


ID

GenoType® MTBDRplus pattern


RIF

INH

rpoB

katG

inhA

RIF

INH

RIF

INH

007–035

S

S

WT

WT

WT

S

S

R

R

007–060

S

R

WT

Δwt S315T1

WT

S

S

S

S

007–069

R

R

Δ8

S531L

WT

WT, C15T

S

S

R

S

007–086

R

R

Δ7,Δ8

WT

S315T1

WT

S

S

S

S

007–088

R

R

Δ8

S531L

Δwt S315T1

WT

S

S

S

R

007–100

S

S

WT

WT

WT

S

S

S

R

007–121

S

R

WT

WT

S315T1

WT

R*

R**

R

R

007–127

S

R

WT

WT

S315T1

WT

S

S

S

S

007–141

R

R

Δ8

S531L

WT

S315T1

Δwt C15T

S

R**

S

S

007–149

S

R

WT

Δwt S315T1

WT

n/a

n/a

R

S

007–153

R

R

Δ8

S531L

Δwt S315T1

WT

S

R***

S

R

007–166

S

S

WT

WT

WT

n/a

n/a

R

R


Notes: ΔN (N = 2...8) – missing WT probe

WT – all WT probes are present

Δwt – missing WT probe(s)

* – GenoType® MTBDRplus pattern Δ8 S531L

** – GenoType® MTBDRplus pattern WT S315T1

*** – GenoType® MTBDRplus pattern Δwt S315T1

Nikolayevskyy et al. BMC Clinical Pathology 2009 9:2   doi:10.1186/1472-6890-9-2

Open Data