Unsupervised hierarchical clustering analysis of genomic similarities between synchronously diagnosed unilateral and bilateral tumor pairs from 16 breast cancer patients. A. Dark blue boxes represent unilateral tumor pairs from the same patient displaying genomic similarities. Light blue boxes represent genomically dissimilar unilateral tumor pairs. The orange box represents a bilateral tumor pair displaying genomic similarities, and yellow boxes represent genomically dissimilar bilateral tumor pairs. Patient number 10 was diagnosed with three synchronous tumors, resulting in one unilateral tumor pair and two bilateral pairs (light blue and yellow boxes). B. The addition of two matched lymph nodes (white boxes marked by a red star) to the unsupervised hierarchical clustering analysis resulted in the two lymph nodes clustering with the tumor pair from the corresponding patient.
Brommesson et al. BMC Clinical Pathology 2008 8:6 doi:10.1186/1472-6890-8-6