|
The level of protein expression of different studied markers in normal, dysplastic and neoplastic cervical epithelium detected by immunohistochemistry |
||||||||||
| Marker |
NCT (20) |
CINI (n = 18) |
CINII (n = 11) |
CINIII (n = 38) |
ISCC (n = 43) |
|||||
| Pos. Cases |
PI* |
Pos. cases |
PI |
Pos. cases |
PI |
Pos. cases |
PI |
Pos. cases |
PI |
|
|
|
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| Ki-67 |
5 (25%) |
< 0.1 |
6.5 ± 0.5 |
10 ± 0.45 |
21.6 ± 9 |
40.5 ± 11 |
||||
| Cyclin D1 |
0(0%) |
0(0%) |
0 (0%) |
5(13.1%) |
24.7 ± 3.6 |
18(41.9%) |
63.2 ± 10.8 |
|||
| Cyclin E |
0(0%) |
3(16.7%) |
18 ± 1.1 |
4(36.4%) |
30 ± 4.4 |
21(55.3%) |
60 ± 10.2 |
38(88.4%) |
97 ± 13.8 |
|
| CDK4 |
0(0%) |
2(11.1%) |
5 ± 0.5 |
4(36.4%) |
12 ± 1.7 |
17(44.7%) |
35 ± 4.6 |
40(93%) |
92 ± 14.7 |
|
| p53 |
0(0%) |
0(0%) |
0(0%) |
7(18.4%) |
44 ± 5.6 |
19(44.2%) |
76 ± 9.1 |
|||
| p21waf1 |
3(15%) |
2.8 ± 0.2 |
1(5.5%) |
7 ± 0.5 |
1(9.1%) |
9.2 |
16(42.1%) |
58 ± 7.1 |
29(67.4%) |
89 ± 10.6 |
| mdm-2 |
0(0%) |
0(0%) |
0(0%) |
9(23.7%) |
66 ± 8.2 |
22(51.2%) |
89 ± 10 |
|||
| p27KIP1 |
20(100%) |
90 ± 8.6 |
18(100%) |
77 ± 10.5 |
7(63.6%) |
60 ± 11.7 |
10(26.3%) |
20 ± 5.5 |
6(13.9%) |
9 ± 1.1 |
| p16INK4A |
0(0%) |
0(0%) |
4(36.4%) |
24 ± 4.7 |
24(63.1%) |
70 ± 12.6 |
40(93%) |
98 ± 12.0 |
||
| Rb† |
0 |
74 ± 11.6 |
0 |
68 ± 11.1 |
6(54.5%) |
54 ± 8.6 |
21(55.2%) |
25 ± 1.6 |
29 (67.4%) |
7 ± 1.0 |
|
PI = Positivity index †: Altered expression | ||||||||||
Bahnassy et al. BMC Clinical Pathology 2007 7:4 doi:10.1186/1472-6890-7-4 |
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