Table 3

The level of protein expression of different studied markers in normal, dysplastic and neoplastic cervical epithelium detected by immunohistochemistry

Marker

NCT (20)

CINI (n = 18)

CINII (n = 11)

CINIII (n = 38)

ISCC (n = 43)

Pos. Cases

PI*

Pos. cases

PI

Pos. cases

PI

Pos. cases

PI

Pos. cases

PI


Ki-67

5 (25%)

< 0.1

6.5 ± 0.5

10 ± 0.45

21.6 ± 9

40.5 ± 11

Cyclin D1

0(0%)

0(0%)

0 (0%)

5(13.1%)

24.7 ± 3.6

18(41.9%)

63.2 ± 10.8

Cyclin E

0(0%)

3(16.7%)

18 ± 1.1

4(36.4%)

30 ± 4.4

21(55.3%)

60 ± 10.2

38(88.4%)

97 ± 13.8

CDK4

0(0%)

2(11.1%)

5 ± 0.5

4(36.4%)

12 ± 1.7

17(44.7%)

35 ± 4.6

40(93%)

92 ± 14.7

p53

0(0%)

0(0%)

0(0%)

7(18.4%)

44 ± 5.6

19(44.2%)

76 ± 9.1

p21waf1

3(15%)

2.8 ± 0.2

1(5.5%)

7 ± 0.5

1(9.1%)

9.2

16(42.1%)

58 ± 7.1

29(67.4%)

89 ± 10.6

mdm-2

0(0%)

0(0%)

0(0%)

9(23.7%)

66 ± 8.2

22(51.2%)

89 ± 10

p27KIP1

20(100%)

90 ± 8.6

18(100%)

77 ± 10.5

7(63.6%)

60 ± 11.7

10(26.3%)

20 ± 5.5

6(13.9%)

9 ± 1.1

p16INK4A

0(0%)

0(0%)

4(36.4%)

24 ± 4.7

24(63.1%)

70 ± 12.6

40(93%)

98 ± 12.0

Rb†

0

74 ± 11.6

0

68 ± 11.1

6(54.5%)

54 ± 8.6

21(55.2%)

25 ± 1.6

29 (67.4%)

7 ± 1.0


PI = Positivity index

†: Altered expression

Bahnassy et al. BMC Clinical Pathology 2007 7:4   doi:10.1186/1472-6890-7-4

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