p27 expression was detected by the pThr187 Ab p27 only in the proliferative compartments of normal tissues. In tonsil (A) both parabasal squamous cells and lymphoid germinal cells were stained. In intestinal epitehlium only the nuclei of deep crypt cells were stained (B). Within the germinal centres, the outer rim of centroblasts and mitotic cells were strongly positive for pThr187-p27, whereas centrocytes were less labelled (C). Trophoblastic villi of placenta show pThr187-p27 intense staining only in the cytotrophoblastic layer and not in the syncytiotrophoblastic layer (D).
Troncone et al. BMC Clinical Pathology 2005 5:3 doi:10.1186/1472-6890-5-3