Table 1

PI3K expression patterns in normal human tissues.

Human Tissues

  n  

Histological Structure

p85

PI3K-C2α

PI3K-C2β

Figure


Digestive system

Stomach

3

Peptic (chief) cells

+++

++

++

2A

Parietal (oxyntic) cells

-

-

-

Gastric mucous cells

-

-

-

Small intestine

7

Enterocytes

+++

++

+

2B

Paneth cells

++

-

-

Goblet cells

-

-

-

Colon

10

Colonocytes

++

++

++

2C

Goblet cells

-

-

-

Features common to all GIT

Mononuclear cells

+++

++

+++

2D

Muscular layers

-

++

-

Ganglion cells

+++

-

+++

2E

Non-myelinated nerves

-

-

++

2E

Neuroendocrine cells

-

-

-

Respiratory system

Lung

5

Pneumocytes (Types I and II)

-

-

-

Alveolar Macrophages

++

++

++

2F

Bronchi

Bronchial Epithelium

+

+

+

Bronchial glands

-

-

-

Cartilage

-

-

-

Bronchial smooth muscle

-

++

-

Skin and Integument

5

Stratified squamous epithelium

-

-

-

2G

Melanocytes

-

-

-

Sebaceous glands

+

-

-

2G

Hair follicle

+

-

-

2H

Sweat Glands

+

+

-

2H

Langerhans cells

++

-

-

2I

Dermal macrophages

++

++

++

2I

Female reproductive system

Uterus

3

Proliferative Endometrium

++

-

-

2J

3

Secretory Endometrium

+

-

-

2K

Endometrial Stroma

-

-

-

Myometrium

-

++

-

Cervix

3

Ectocervical squamous epithelium

-

-

-

Endocervical glands

-

-

-

2L

Cervical smooth muscle

-

++

-

Ovary

3

Follicular cells

++

+

+

2M

Germinal cells

-

-

-

Stromal cells

-

-

-

Corpus luteum

ND

ND

ND

Fallopian tube

2

Columnar ciliated epithelium

+++

++

+

2N

Mammary gland (breast)

3

Luminal acinar epithelium

-

-

-

2O

Myoepithelial cells

-

+

-

Lactiferous ducts

-

+

-

Male reproductive system

Testis

3

Spermatogenic cells

+++

-

+++ *

2P, 2Q *

Sertoli cells

-

-

-

Leydig cells

++

+++

++

Prostate gland

10

Basal Epithelium

-

+

-

Luminal epithelium

-

-

-

Fibromuscular stroma

-

++

-

Urinary system

Urinary bladder

5

Transitional epithelium

++

++

++

2R

Muscularis

-

++

-

Kidney

10

Glomerular macrophages

++

-

++

3A

Glomerular tuft

-

+++

-

3B

Proximal Tubules

-

+

+

Macula Densa

++

-

-

3A

Distal tubules

-

+

+

Collecting tubules

+++

+

+

Pancreas

5

Acini

+++

++

-

3C, 3D

Ducts

-

++

-

3D

Islets of Langerhans

-

-

-

3C

Hepatobiliary system

Liver

4

Hepatocytes

-

-

-

Bile ducts

-

++

-

Kupffer cells

-

-

-

Gall bladder

4

Lining epithelium

+

+

+

Smooth muscle layer

-

++

-

Mononuclear cells

++

++

++

Endocrine System

Thyroid

3

Follicular/Parafollicular

-

-

-

Parathyroid

3

Oxyphil/Chief

-

-

-

Endocrine Pancreas

Islets of Langerhans

-

-

-

Lymphoid tissue & Immune cells

Spleen

5

White pulp

-

-

-

Red pulp (mononuclear cells)

++

+

++

3E

Red pulp (splenic sinusoids)

-

+++

-

3F

Lymph nodes

5

Lymphoid follicles

-

-

-

Germinal centre mononuclear cells

++

+

+

Medulla (mononuclear cells)

++

+

++

Tissue macrophages

+++

++

++

3G

Polymorphnuclear leucocytes

+

+++

-

3H


Abbreviations and symbols used: ND: Not determined; - undetectable; + weak; ++ moderate or +++ strong. Reactivity for PI3K-C2α in venous and capillary endothelium was not included in the tissue staining results. *Expression of PI3K-C2β was nuclear in spermatocytes.

El Sheikh et al. BMC Clinical Pathology 2003 3:4   doi:10.1186/1472-6890-3-4

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