Figure 10.

Carcinoma Hybridized with HPV Probe. A. HPV hybridization signals in a cervical squamous cell carcinoma demonstrated with AEC (applied for 10 minutes). B. A section from the same carcinoma with hybridization signal demonstrated with DAB (applied for 3 minutes). A given signal is more intense with DAB than with AEC, however overall the information about the carcinoma that is gained with DAB is also obtained with AEC as a similar proportion of cells demonstrate 1 or 2 HPV signals after application of either substrate. Background is relatively clean with DAB on this sample. Scale Bar: 10μm