Table 4

Multivariate analyses of clinopathological variables and angiogenic markers as prognostic values for disease-specific survival, metastasis and local recurrence in patients with resected soft-tissue sarcomas of the trunk or extremities (cox proportional hazards test)
Disase-specific survival Metastasis-free survival Recurrence-free survival
Variable HR 95% CI P HR 95% CI P HR 95% CI P
Extremity & trunk
Malignancy grade
1 1.000 <0.001*
2 4.066 1.389-11.901 0.010
3 6.025 2.058-17.634 0.001
Vascular invasion
Absent 1.000 1.000 1.000
Present 2.141 1.188-3.859 0.011 5.284 2.418-11.544 <0.001 2.135 1.019-4.475 0.045
Resection margins
Wide 1.000 1.000
Non-wide 1.818 1.032-3.203 0.039 2.687 1.289-5.602 0.008
PDGF-B
Low 1.000
High 2.099 0.937-4.706 0.072
PDGF-D
Low 1.000 1.000
High 1.863 1.057-3.283 0.031 1.844 0.931-3.653 0.079
VEGF-A
Low 1.000
High 2.095 1.028-4.271 0.042
VEGFR-1
Low 1.000
High 2.106 1.038-4.272 0.039
Visceral & retroperitoneal
Gender
Male 1.000
Female 4.612 1.089-19.536 0.038
Malignancy grade
1 1.000 0.003* 1.000 0.061
2 4.812 1.823-12.705 0.002 2.069 0.630-6.794 0.231
3 5.646 1.790-17.804 0.003 5.665 1.330-24.123 0.019
Resection margins
Wide 1.000 1.000
Non-wide 2.712 1.222-6.018 0.014 11.996 3.128-46.005 <0.001
PDGF-C
Low 1.000
High 0.413 0.157-1.089 0.074
FGFR-1
Low 1.000
High 0.243 0.095-0.618 0.003

Abbreviations: HR Hazard ratio, CI Confidence interval, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, PDGFR Platelet-derived growth factor receptor, FGFR Fibroblast growth factor receptor, *overall significance as prognostic factor.

Kilvaer et al.

Kilvaer et al. BMC Clinical Pathology 2014 14:5   doi:10.1186/1472-6890-14-5

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