Table 3

Angiogenic markers as predictors for disease-specific survival, metastasis and local recurrence in patients with resected visceral & retroperitoneal soft-tissue sarcomas (univariate analyses, log rank test, n = 66)
Disase-specific survival Metastasis-free survival Recurrence-free survival
Marker expression Patients (n) 5-Year survival (%) P 5-Year survival (%) P 5-Year survival (%) P
PDGF-A
Low 23 49 0.473 63 0.593 65 0.315
High 39 63 54 73
Missing 4
PDGF-B
Low 14 54 0.604 82 0.088 61 0.291
High 48 59 51 73
Missing 4
PDGF-C
Low 20 39 0.297 59 0.986 53 0.045
High 41 65 56 76
Missing 5
PDGF-D
Low 48 52 0.078 52 0.197 70 0.343
High 15 80 73 59
Missing 3
PDGFR-α
Low 41 56 0.672 61 0.527 71 0.761
High 21 61 51 66
Missing 4
PDGFR-β
Low 58 57 0.360 54 0.532 70 0.766
High 4 75 75 75
Missing 4
VEGF-A
Low 34 51 0.326 64 0.719 64 0.054
High 29 68 53 79
Missing 3
VEGF-C
Low 34 66 0.402 69 0.071 62 0.051
High 29 50 45 84
Missing 3
VEGF-D
Low 34 60 0.856 62 0.388 63 0.116
High 30 55 51 78
Missing 2
VEGFR-1
Low 37 55 0.724 63 0.358 70 0.510
High 25 63 49 71
Missing 3
VEGFR-2
Low 44 55 0.858 63 0.446 69 0.821
High 19 67 48 75
Missing 3
VEGFR-3
Low 36 54 0.552 59 0.821 65 0.220
High 25 61 52 76
Missing 5
FGF2
Low 39 56 0.805 51 0.214 74 0.748
High 20 65 67 66
Missing 7
FGFR-1
Low 43 45 0.023 56 0.385 68 0.448
High 20 89 63 78
Missing 3

Abbreviations: PDGF Platelet-derived growth factor, PDGFR Platelet-derived growth factor receptor, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, FGF Fibroblast growth factor, FGFR Fibroblast growth factor receptor.

Kilvaer et al.

Kilvaer et al. BMC Clinical Pathology 2014 14:5   doi:10.1186/1472-6890-14-5

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