Open Access Research article

Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer

Sukru Atakan1, Hulya Bayiz2, Serpil Sak3, Alper Poyraz1, Burcak Vural5, Azmi Serhat Yildirim1, Funda Demirag4 and Ali Osmay Gure1*

Author Affiliations

1 Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey

2 Department of Thoracic Medicine, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey

3 Department of Pathology, Ankara University, Ankara, Turkey

4 Department of Pathology, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey

5 Department of Genetics, Institute for Experimental Medicine, Istanbul University School of Medicine, Istanbul, Turkey

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BMC Clinical Pathology 2014, 14:24  doi:10.1186/1472-6890-14-24

Published: 7 June 2014

Additional files

Additional file 1: Figure S1:

Scatter dot plot of SOX2 ELISA. The median values for small cell lung cancer (SCLC) and healthy control sera (CTR), as well as the cut-off for seropositivity (dotted line) are shown. Figure S2. Kaplan-Meier analysis of patients stratified according to SOX2 seropositivity. Although seropositive patients show a trend for better overall survival the difference, as calculated by the log-rank test, is insignificant (p=0.3).

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