Study design. On postoperative day 0 (POD0), 6-millimeter diameter wounds were created in the central area of the ventral ear down to the perichondrium. On POD3, wounds were inoculated with either P. aeruginosa or K. pneumoniae (106 CFU/wound). On POD 4, topical ciprofloxacin ointment was applied. Antimicrobial absorbent dressing changes were made on PODs 5, 6 and every second day until wound harvest. Wounds were harvested on PODs 4, 6 and 12 by excision using a 7-millimeter biopsy punch, and RNA was isolated for microarray analysis.
Leung et al. BMC Clinical Pathology 2014 14:20 doi:10.1186/1472-6890-14-20