Photomicrographs of non-MYCN amplified neuroblastoma demonstrating: A. Neuroblastoma with widespread neuritic processes. Tumour cells are small and round and do not show ganglion cell differentiation at this stage. Original magnification ×1000. B. The image demonstrates abundant sheaves of microtubules and neurites in transverse section with many electron dense neurosecretory granules. Original magnification ×3000. C. A high power view of a neurite process with dense-core, neurosecretory granules with a characteristic peripheral halo. The mean diameter of the granules in all cases was 98 nm. Original magnification ×15000.
Latimer et al. BMC Clinical Pathology 2014 14:13 doi:10.1186/1472-6890-14-13