Table 1

Clinical characteristics of 54 patientsa in relation to immunohistochemical staining for GAPDH, PKM2 and ATP5B
GAPDH PKM2 ATP5B
n = 54 n = 54 n = 54
Characteristic low <50% 2+ high ≥50% 2+ low <20% 3+ high ≥20% 3+ low 1-2+ high 3+
n = 26 n = 28 n = 26 n = 28 n = 26 n = 28
N (%) N (%) N (%) N (%) N (%) N (%)
Age at diagnosis (years)
  Median 64.5 (39–83) NA NA NA NA NA NA
Diagnosis
  Epithelial ovarian (n = 41) 22 (54) 19 (46) 23 (56) 18 (44) 21 (51) 20 (49)
  Fallopian tube (n = 10) 4 (40) 6 (60) 4 (40) 6 (60) 4 (40) 6 (60)
  Peritoneal (n = 3) 0 3 (100) 0 3 (100) 1 (33) 2 (67)
FIGO stage
  IIC (n = 2) - IIIB (n = 3) 2 (40) 3 (60) 1 (20) 4 (80) 5 (100) 0
  IIIC (n = 42) 21 (50) 21 (50) 21 (50) 21 (50) 18 (43) 24 (57)
  IV (n = 7) 3 (43) 4 (57) 4 (57) 3 (43) 3 (43) 4 (57)
Subtype
  Serous (n = 47) 22 (47) 25 (53) 19 (40) 28 (60) 23 (49) 24 (51)
  Endometrioid (n = 7) 4 (57) 3 (43) 7 (100) 0 3 (43) 4 (57)
Grade of differentiationb
  High (n = 4) 2 (50) 2 (50) 1 (25) 3 (75) 2 (50) 2 (50)
  Moderate (n = 4) 2 (50) 2 (50) 2 (50) 2 (50) 2 (50) 2 (50)
  Poor (n = 46) 22 (48) 24 (52) 23 (50) 23 (50) 22 (48) 24 (52)
Postop residual tumor size
  0 mm (n = 6) 3 (50) 3 (50) 0 6 (100) 4 (67) 2 (33)
  1-10 mm (n = 10) 4 (40) 6 (60) 3 (30) 7 (70) 5 (50) 5 (50)
  >10 mm (n = 38) 19 (50) 19 (50) 23 (61) 15 (39) 17 (45) 21 (55)
1st line Chemotherapy
  Carboplatin + paclitaxel (n = 47) NA NA NA NA NA NA
  Other platinum based (n = 7)
Time from EOT to recurrence/progression
  < 6 months (n = 25) 10 (40) 15 (60) 13 (52) 12 (48) 8 (32) 17 (68)
  ≥ 6 months (n = 28) 16 (57) 12 (43) 13 (46) 15 (54) 17 (61) 11 (39)
  Unknown (n = 1) 0 1 (100) 0 1 (100) 1 (100) 0
Survival
  Alive, no evidence of disease (n = 8) 4 (50) 4 (50) 2 (25) 6 (75) 6 (75) 2 (25)
  Alive, with disease (n = 9) 6 (67) 3 (33) 4 (44) 5 (56) 5 (56) 4 (44)
  Death from disease (n = 36) 16 (44) 20 (56) 19 (53) 17 (47) 14 (39) 22 (61)
  Death from other cause (n = 1) 0 1 (100) 1 (100) 0 1 (100) 0

Abbreviations: FIGO, Federation Internationale de Gynecologie et d’Obstetrique, EOT, End of treatment, NA, Not applicable.

aTumor blocks could be retrieved in 54 of 56 cases.

bGrade of differentiation according to WHO international histological classification of tumors.

Hjerpe et al.

Hjerpe et al. BMC Clinical Pathology 2013 13:30   doi:10.1186/1472-6890-13-30

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