Table 2

Metabolic ratios of urinary estrogens between benign tumors and malignant Papillary Thyroid Carcinomas (PTCs) in postmenopausal women
Metabolic ratio (product/precursor) Benign tumor (a) (n= 9) Malignant PTCs P-value2
Stage I (b) Stage III/IV (c) P-value1 a vs. b a vs. c b vs. c
(n= 11) (n= 7)
2-hydroxylase
 2-OH-E1/E1 0.16 ± 0.14 0.13 ± 0.09 0.16 ± 0.15 0.991
 2-OH-E2/E2 0.75 ± 0.40 0.38 ± 0.30 0.47 ± 0.29 0.070
4-hydroxylase
 4-OH-E1/E1 0.10 ± 0.13 0.12 ± 0.09 0.15 ± 0.08 0.182
 4-OH-E2/E2 0.64 ± 0.44 0.42 ± 0.28 0.40 ± 0.20 0.360
16α-hydroxylase
 16α-OH-E1/E1 0.12 ± 0.09 0.26 ± 0.20 0.31 ± 0.20 0.052 0.095 0.012 0.659
 E3/E2 2.16 ± 1.10 4.72 ± 3.28 6.66 ± 3.27 0.007 0.067 0.001 0.126
Methyltransferase
 2-MeO-E1/2-OH-E1 1.43 ± 0.94 1.68 ± 1.00 1.66 ± 0.93 0.838
 2-MeO-E2/2-OH-E2 6.35 ± 8.80 4.98 ± 5.47 3.55 ± 4.53 0.935
 4-MeO-E1/4-OH-E1 3.23 ± 6.88 0.25 ± 0.18 0.58 ± 0.47 0.140
 4-MeO-E2/4-OH-E2 4.02 ± 7.28 0.83 ± 0.57 1.20 ± 0.60 0.216
17β-hydroxysteroid dehydrogenase
 E2/E1 0.10 ± 0.08 0.23 ± 0.22 0.26 ± 0.08 0.013 0.046 0.002 0.285
 E3/16α-OH-E1 1.75 ± 0.80 3.79 ± 1.80 6.15 ± 2.18 0.001 0.010 0.0001 0.044
2-/16α-hydroxylation
 2-OH-E1/16α-OH-E1 2.05 ± 2.46 0.82 ± 0.74 0.64 ± 0.58 0.110
 2-OH-E2/E3 0.50 ± 0.46 0.11 ± 0.14 0.08 ± 0.06 0.022 0.020 0.012 0.930

The metabolic ratios are presented as the metabolite-to-precursor ratio in each subject (mean ± SD).

Statistical significance was determined with nonparametric 1Kruskal-Wallis and 2Mann-Whitney U tests to evaluate possible differences in the diagnostic factors.

The significant metabolic ratios with P < 0.05 in the Kruskal-Wallis test were then compared with the Mann–Whitney U test between 2 groups, including benign versus stage I PTC (a vs. b), benign versus stage III/IV PTC (a vs. c), and stage I versus stage III/IV PTC (b vs. c). A Bonferroni correction was applied to the post hoc analysis of the between-group comparisons performed for each variable and to set the significance level at 0.017.

Moon et al.

Moon et al. BMC Clinical Pathology 2013 13:25   doi:10.1186/1472-6890-13-25

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