Table 1

Urinary estrogen concentrations associated with benign tumors and malignant Papillary Thyroid Carcinomas (PTCs) in the postmenopausal women
Compounds (trivial name) Benign tumor (a) (n= 9) Malignant PTCs P-value2
Stage I (b) (n= 11) Stage III/IV (C) (n= 7) P-value1 a vs. b a vs. c b vs. c
Estrone (E1) 12.1 ± 11.3 2.9 ± 2.3 5.0 ± 6.5 0.053 0.020 0.091 0.791
17β-estradiol (E2) 0.8 ± 0.6 0.4 ± 0.2 1.1 ± 1.3 0.416
Estriol (E3) 1.7 ± 1.7 1.9 ± 1.7 6.2 ± 6.7 0.146
2-hydroxyestrone (2-OH-E1) 2.2 ± 3.5 0.3 ± 0.3 0.7 ± 1.2 0.073
2-hydroxy-17β-estradiol (2-OH-E2) 0.5 ± 0.4 0.1 ± 0.1 0.3 ± 0.2 0.052 0.031 0.536 0.085
4-hydroxyestrone (4-OH-E1) 0.6 ± 0.5 0.3 ± 0.3 0.4 ± 0.4 0.558
4-hydroxy-17β-estradiol (4-OH-E2) 0.5 ± 0.4 0.1 ± 0.1 0.2 ± 0.1 0.182
2-methoxyestrone (2-MeO-E1) 1.6 ± 1.7 0.5 ± 0.4 0.6 ± 0.6 0.108
2-methoxy-17β-estradiol (2-MeO-E2) 1.4 ± 1.1 0.4 ± 0.3 0.6 ± 0.4 0.034 0.012 0.114 0.285
4-methoxyestrone (4-MeO-E1) 0.6 ± 0.8 0.1 ± 0.1 0.2 ± 0.4 0.011 0.004 0.174 0.179
4-methoxy-17β-estradiol (4-MeO-E2) 0.3 ± 0.7 0.1 ± 0.1 0.2 ± 0.2 0.104
17-epiestriol (17-epi-E3) 0.3 ± 0.3 0.1 ± 0.1 0.1 ± 0.1 0.029 0.016 0.142 0.425
16-epiestriol (16-epi-E3) 0.7 ± 0.9 0.3 ± 0.2 0.9 ± 1.0 0.589
16α-hydroxyestrone (16α-OH-E1) 0.9 ± 0.7 0.6 ± 0.6 0.8 ± 0.8 0.462
16-keto-17β-estradiol (16-keto-E2) 0.7 ± 0.9 0.6 ± 0.6 0.7 ± 1.0 0.803

Concentrations are expressed as ng/mg of creatinine (mean ± SD).

Statistical significance was determined by a nonparametric 1Kruskal-Wallis and 2Mann-Whitney U test to evaluate possible differences in the diagnostic factors.

The significant estrogens with P < 0.05 in a Kruskal-Wallis test were then compared with the Mann–Whitney U test results between 2 groups, including benign versus stage I PTC (a vs. b), benign versus stage III/IV PTC (a vs. c), and stage I versus stage III/IV PTC (b vs. c). A Bonferroni correction was applied to the post hoc analysis of the between-group comparisons performed for each variable and to set the significance level at 0.017.

Moon et al.

Moon et al. BMC Clinical Pathology 2013 13:25   doi:10.1186/1472-6890-13-25

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