Differential metabolic ratios on estrogen metabolism with statistical significance in benign and malignant papillary thyroid tumors. Estrogen activities were compared in postmenopausal women with benign adenomas (n = 9) and stage I (n = 11) and III/IV (n = 7) malignant carcinomas. The significant metabolic ratios with P < 0.05 in a Kruskal-Wallis test were analyzed with the Mann–Whitney U test between 2 groups, including benign versus stage I PTC, benign versus stage III/IV PTC, and stage I versus stage III/IV PTC. (A) 16α-OH-E1/E1, (B) E3/E2, (C) E2/E1, (D) E3/16α-OH-E1 and (E) 2-OH-E2/E3. * P < 0.02; ** P < 0.002; and *** P < 0.0002.
Moon et al. BMC Clinical Pathology 2013 13:25 doi:10.1186/1472-6890-13-25