Table 2

Literature review of clinicopathological data of primary thymic adenocarcinomas
Author Year Sex Age Symptoms Tumor type Site RX Outcome Associated findings
Moriyama S [2] 1989 F 51 Hyperthyroidism Papillo-tubular Right lobe of the thymus S No recurrence for 14 years Multiple thymic cysts
Babu MK [19] 1994 M 50 NA Conventional NA Alive after 4 months Congenital thymic cyst
Makino Y [6] 1998 M 39 Chest pain Papillary carcinoma NA S,R Alive after 5 months NA
Matsuno [5] 1998 M 70 Not mentioned Papillary carcinoma Anterior mediastinum S,R Recurrence after 8 months Numerous psammoma bodies
F 69 Not mentioned Papillary carcinoma Left lower pole of the thymus S Not mentioned Thymoma of medullary type
F 61 Not mentioned Papillary carcinoma Substernalmediastinal mass S,R,C Died after 7 months Chronic elephantiasis nostrasverrucosum in skin
M 57 Not mentioned Papillary carcinoma Anterior mediastinum S,R,C Alive after 5 years No
Shimono [20] 2001 M 61 facial edema, general fatigue Not specified Anterior mediastinum S,R,C Alive after 53 months No
Zaitlin [21] 2003 F 51 Asymptomatic Papillary carcinoma Anterior left mediastinum S,R Died after 26 months Thymic cyst
Choi WW [7] 2003 M 39 Cough&lethargy Papillary carcinoma Anterior mediastinum S,R,C Alive after 3 years NA
M 15 Dry cough Mucinous carcinoma Right anterior mediastinum S,R Died after 26 months Thymiccyst&cribriform, carcinomatous gland in thymic medulla
Misao [10] 2004 M 59 Accidental finding in chest x ray Not specified Anterior Mediastinum S,C Died after 24 months No
Takahashi F [1] 2004 M 49 Accidental finding in chest x ray Mucinous carcinoma Anterior mediastinum R Died 11 months after DX Increased CA19-9, CEA
Seki, ErinaMD [11] 2004 M Left shoulder pain Mucinous adenocarcinoma with pleural dissemination Anterior mediastinum R.C Alive in 11 months after surgery. No
Yoshino M [12] 2005 F 29 Accidental finding in chest x ray Papillary carcinoma Anterior mediastinum S Not mentioned Type A thymoma, Psammoma bodies and follicles
PayalKapur [4] 2006 M 41 Not mentioned Mucinous carcinoma Anterior mediastinum R,c 2 recurrence in 3 years Multiple thymic cysts
ToyomitsuSawai [9] 2006 M 34 Accidental finding in chest x ray Moderately differentiated adenocarcinoma Right anterior mediastinum R,C Lung metastasis after eight months of surgery Increased CA19-9, CEA
Seong H. Ra [13] 2007 F 61 Hoarseness, dysphagia, left shoulder pain, and fatigue Mucinous carcinoma Superoanterior mediastinum S,R Metastatic disease to retroperitoneal lymph nodes at 5 months Psammoma bodies
F 82 Shortness of breath, chest tightness, back stiffness, and weight loss of 15 lb Mucinous carcinoma Anterior mediastinum S Passed away due to surgical complications Thymiccyst, signetringlike features
Furtado [14] 2008 M 44 Accidental finding in chest x ray Papillary carcinoma Pretracheal region S,R,C Alive for 24 months Psammoma bodies
HosakaY [15] 2009 M 36 Accidental finding in chest x ray Moderately differentiated adenocarcinoma with papillary formation Right anterior mediastinum R Alive in 11 years after surgery Type AB thymoma
Toshiji I [16] 2009 M 54 Cough, fever, dyspnea,chest pain, facial edema Poorly differentiated sarcomatoid tumor cells partially composed of papillotubular adenocarcinoma Anterior mediastinum R Passed away 56 days after the initialsymptoms Slight elevation of sialyl Lewis-x antigen,soluble interleukin-2 receptor
Maeda D [17] 2009 F 52 Bulging of the left parasternal region Mucinous carcinoma Anterior mediastinum S,R,C Lung metastasis after 7 months Thymic cyst
M 38 Chest pain Mucinous carcinoma Anterior mediastinum S,R,C Died 12 months after diagnosis No
M 55 Chest tightness Mucinous carcinoma Anterior mediastinum S,R,C Died 24 months after diagnosis No
Yong Joon Ra [18] 2010 M 68 Dyspnea and chest pain on left anteriorchest Conventional Anterior mediastinam Not mentioned Not mentioned Slightly increased (β-hCG) level
Current case 2010 F 28 Neck and right upper extremity pain and dyspnea Mucinous Anterior mediastinam S,R,C Two recurrences in two years follow up Thymic cyst and psammoma bodies, increased CA19-9

Abbreviations: NA not available, S Surgery, R Radiotherapy, C Chemotherapy, Thy Thymectomy.

Maghbool et al.

Maghbool et al. BMC Clinical Pathology 2013 13:17   doi:10.1186/1472-6890-13-17

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