Table 4

Analysis of IHC expression of Integrins expression according to covariates in patients with CRC (n = 114)
Covariates Categorization Integrins
αV α3 α5 α6 β5
- / + p - / + p - / + p - / + p - / + p
Age < 60 years 27/29 0.259 27/29 1.00 49/7 <0.001 30/26 1.000 30/26 0.851
≥ 60 years 35/23 28/30 4/54 31/27 33/25
Gender Male 34/29 1.000 28/35 0.451 29/34 1.000 36/27 0.452 35/28 1.00
Female 28/23 27/24 24/27 25/26 28/23
Histological type Adeno 54/43 0.601 48/49 0.502 51/ 46 0.003 61/36 0.002 53/44 0.684
Mucinous 8/9 7/10 2/15 0/17 10/7
Tumor grading Low grade 56/44 0.401 50/50 0.397 48/52 0.569 57/43 0.083 57/43 0.394
High grade 6/8 5/9 5/9 4/10 6/8
Venous invasion Absent 58/35 <0.001 52/41 0.001 42/51 0.631 61/32 <0.001 54/39 0.239
Present 4/17 3/18 11/10 0/21 09/12
Perineural invasion Absent 62/44 0.001 52/54 0.781 49/57 1.000 59/47 0.142 60/46 0.464
Present 0/8 3/5 4/4 2/6 3/5
Clinical stage I-II 59/5 <0.001 53/11 <0.001 28/36 0.572 40/24 0.038 49/15 <0.001
III- IV 3/47 2/48 25/25 21/29 14/36

-/+ = Low/high expression; Adeno.,Adenocarcinoma. Significant values are bold.

Denadai et al.

Denadai et al. BMC Clinical Pathology 2013 13:16   doi:10.1186/1472-6890-13-16

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