Open Access Research article

Expression profiling of 21 biomolecules in locally advanced nasopharyngeal carcinomas of Caucasian patients

Dimitrios Krikelis1*, Mattheos Bobos2, Georgia Karayannopoulou3, Liliana Resiga4, Sofia Chrysafi2, Epaminontas Samantas5, Dimitrios Andreopoulos6, Vassilios Vassiliou6, Elisabeta Ciuleanu4 and George Fountzilas1

Author Affiliations

1 Department of Medical Oncology “Papageorgiou” Hospital, Aristotle University of Thessaloniki School of Medicine, Ring Road of Thessaloniki, Nea Efkarpia, Thessaloniki, PC, 56403, Greece

2 Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

3 Department of Pathology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

4 Department of Pathology, “Ion Chiricuta” Cancer Institute, Cluj, Romania

5 Third Department of Medical Oncology, “Agii Anargiri” Cancer Hospital, Athens, Greece

6 Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus

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BMC Clinical Pathology 2013, 13:1  doi:10.1186/1472-6890-13-1

Published: 29 January 2013

Additional files

Additional file 1:

Figure S1. Protein expression detected by IHC and CISH in tissue microarrays from nasopharyngeal carcinoma cases. (a) p53; (b) EGFR; (c) COX-2; (d) VEGF-A; (e) MAPT; (f) E-cadherin; (g) PTEN; (h) p-GSK-3β; (i) VEGF-C; (j) ERCC1; (k) Fascin-1; (l) p-AKT; (m) p-p44/42 MAPK; (n) VEGFR-2; (o) Cyclin D1; (p) P-cadherin; (q) p-mTOR; (r) p63; (s) VEGFR-3; (t) Ki67; (u) Multi-Cytokeratin; (v) mRNA probe (CISH); (w) EBER probe (CISH). Original magnification ×100.

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Additional file 2:

Table S1. Statistical correlations of biomolecules expression with clinicopathological parameters.

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Additional file 3:

Table S2. Paired associations of protein expression (Fisher’s exact test).

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Additional file 4:

Figure S2. Prognostic significance of EBER, p63, mTOR, ERCC1 and Cyclin D1 protein expression for progression-free and overall survival (Log-Rank test). For Cyclin D1, all patients have been included, irrespective of the treatment administered.

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