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## Figure 2.
Variability in the evaluation of precancerous lesions on histopathology. (A) Intra-rater agreement on the Smith and Pindborg's scores at two time points spaced
3 months apart. The chart shows difference versus average Bland-Altman plot and the
dotted lines represent the mean and 95% confidence interval for the difference. Pitman's
P, significance value for difference in variability in two observations obtained using
Pitman's variance ratio test. (B) Three histopathological evaluations (H1-H3) were available for each specimen. Two
evaluations (H1 and H2) were contributed by the same pathologist at two different
time points, while the third evaluation (H3) was contributed independently by a second
histopathologist. Each lesion was classified as no (code 0), mild (code 1), moderate
(code 2) or severe (code 3) dysplasia. These codes correspond to the Figure 1, panels E through H, respectively. Table shows the number of subjects classified
based on each evaluation. Bar chart to the right shows the within-outcome category
agreement using the kappa statistic. P, significance value of the kappa statistic.
(C) Strategy used for dichotomization of the histopathology results. The colors match
those in panel D. (D) Combinatorial representation of the three histopathological evaluations for latent
class analyses. N, number of subjects. Bar chart to the right shows the estimated
probability of a high-risk lesion (H) for given combination of the three histopathological
evaluations. (E) Bar chart showing the association between total histopathological score and the estimated
probability of a true high-risk lesion. No study subject had a score of 0, 8 or 9.
(F) Pie chart showing the proportion of subjects classified as high risk (pink sector)
or low risk (yellow sector) based on majority vote from the three histopathological
evaluations.
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