Table 6

Mean HER2/CEN-17 ratio and signal numbers for all specimens with a HER2/CEN-17 CISH ratio below 3.

Mean

N

Std. Deviation


HER2/CEN-17 ratio

HER2 CISH

1.28

320

0.28

HER2 FISH

1.27a

317

0.35

PathVysion

1.28b

319

0.40

HER2 signals

HER2 CISH

55.36

320

20.62

HER2 FISH

50.90c

317

20.59

PathVysion

50.59d

319

26.09

CEN-17 signals

HER2 CISH

42.95

320

11.44

HER2 FISH

40.35e

317

12.28

PathVysion

39.52f

319

14.75


Signal copy numbers were normalized to 20 nuclei

a) Not significantly different from CISH ratio in a two tailed, paired t-test (N = 316, P = 0.326)

b) Not significantly different from CISH ratio in a two tailed, paired t-test (N = 318, P = 0.982)

c) Significantly different from CISH HER2 signals in a two tailed, paired t-test (N = 316, P < 0.001)

d) Significantly different from CISH HER2 signals in a two-tailed, paired t-test (N = 318, P < 0.001)

e) Significantly different from CISH CEN-17 signals in a two tailed, paired t-test (N = 316, P < 0.001)

f) Significantly different from CISH CEN-17 signals in a two-tailed, paired t-test (N = 318, P < 0.001)

Mollerup et al. BMC Clinical Pathology 2012 12:3   doi:10.1186/1472-6890-12-3

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