Table 6 

Mean HER2/CEN17 ratio and signal numbers for all specimens with a HER2/CEN17 CISH ratio below 3. 

Mean 
N 
Std. Deviation 



HER2/CEN17 ratio 
HER2 CISH 
1.28 
320 
0.28 
HER2 FISH 
1.27^{a} 
317 
0.35 

PathVysion 
1.28^{b} 
319 
0.40 

HER2 signals 
HER2 CISH 
55.36 
320 
20.62 
HER2 FISH 
50.90^{c} 
317 
20.59 

PathVysion 
50.59^{d} 
319 
26.09 

CEN17 signals 
HER2 CISH 
42.95 
320 
11.44 
HER2 FISH 
40.35^{e} 
317 
12.28 

PathVysion 
39.52^{f} 
319 
14.75 



Signal copy numbers were normalized to 20 nuclei a) Not significantly different from CISH ratio in a two tailed, paired ttest (N = 316, P = 0.326) b) Not significantly different from CISH ratio in a two tailed, paired ttest (N = 318, P = 0.982) c) Significantly different from CISH HER2 signals in a two tailed, paired ttest (N = 316, P < 0.001) d) Significantly different from CISH HER2 signals in a twotailed, paired ttest (N = 318, P < 0.001) e) Significantly different from CISH CEN17 signals in a two tailed, paired ttest (N = 316, P < 0.001) f) Significantly different from CISH CEN17 signals in a twotailed, paired ttest (N = 318, P < 0.001) 

Mollerup et al. BMC Clinical Pathology 2012 12:3 doi:10.1186/14726890123 